Nature, Količina 429Sir Norman Lockyer Macmillan Journals Limited, 2004 |
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Zadetki 1–3 od 8
Stran 87
... COP1 serves as an E3 ubiquitin ligase for p53 in vitro and in vivo , and inhibits p53 - dependent transcription and apoptosis . Depletion of COP1 by short interfering RNA ( siRNA ) stabilizes p53 and arrests cells in the G1 phase of the ...
... COP1 serves as an E3 ubiquitin ligase for p53 in vitro and in vivo , and inhibits p53 - dependent transcription and apoptosis . Depletion of COP1 by short interfering RNA ( siRNA ) stabilizes p53 and arrests cells in the G1 phase of the ...
Stran 88
... COP1 Flag - COP1ARING WB : Flag WB : p53 WB : actins and ca Relative p53 mRNA levels 1 0.8 0.6 220 0.4 Vector COP1 COP1ARING + ALLN Flag vector COP1 COP1ARING Flag vector COP1 COP1ARING h p53 p53 IP : HA WB : p53 P b WB : Flag WB : p53 ...
... COP1 Flag - COP1ARING WB : Flag WB : p53 WB : actins and ca Relative p53 mRNA levels 1 0.8 0.6 220 0.4 Vector COP1 COP1ARING + ALLN Flag vector COP1 COP1ARING Flag vector COP1 COP1ARING h p53 p53 IP : HA WB : p53 P b WB : Flag WB : p53 ...
Stran 89
... COP1 inhibited p53 gene transcription ( Fig . 2c ) . Transfection of Flag - COP1 or Flag - COP1ARING in U2 - OS cells resulted in no significant change in p53 messenger RNA levels . However , using pulse - chase analysis , transfection of ...
... COP1 inhibited p53 gene transcription ( Fig . 2c ) . Transfection of Flag - COP1 or Flag - COP1ARING in U2 - OS cells resulted in no significant change in p53 messenger RNA levels . However , using pulse - chase analysis , transfection of ...
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