Chemical Carcinogens and DNA, Količina 1

7-methylbenz[a]anthracene 7-methylguanine Acad actinomycin adducts formed administration aflatoxin alkylating agents alkylation products animals aromatic B₁ bacteriophage bases benzo[a]pyrene binding Biochem Biol biological Biophys bleomycin bound to DNA Brookes Cancer Res carcin carcinogen-DNA adducts carcinogens cellular Chem chemical carcinogenesis chemical carcinogens chromatography coli covalent cycasin daunomycin deoxyribonucleic acid deoxyribonucleosides depurination derivatives detected dimethylnitrosamine diol-epoxide DNA adducts DNA in vivo dose effects eluted enzyme epoxide excision Figure fluorescence formation guanine hamster hydrolysis inactivation incubation induced inhibition isolated K-region kidney Lawley lesions liver liver DNA liver microsomes mammalian Margison measurements metabolic activation metabolism metabolites methyl mice microsomal Miller miscoding molecule monocrotaline mouse skin mutagenesis mutagenic mutation N-nitroso compounds Natl Nature London nitrosamines nucleic acids nucleosides occur phosphotriesters polycyclic hydrocarbons Proc protein purines pyrrolizidine alkaloids radioactive carcinogens rat liver rat-liver react reactive repair safrole species structure studies techniques tion tissues toxicity Toxicol tritium tumors vitro