WHO Expert Committee on Drug Dependence: Thirty-fifth ReportWorld Health Organization, 2012 - 26 strani This report presents the recommendations of a WHO Expert Committee responsible for reviewing information on psychoactive substances to assess the need for their international control. The report contains a summary of the Committee's evaluations of y-hydroxybutyric acid (GHB) and ketamine. GHB was recommended to be rescheduled from Schedule IV to Schedule II of the Convention on Psychotropic Substances. The report also discusses the nine substances that were prereviewed: dextromethorphan, tapentadol, N-benzylpiperazine (BZP), 1-(3-trifluoromethylphenyl)piperazine (TFMPP), 1-(3-chlorophenyl)piperazine (mCPP), 1-(4-methoxyphenyl) piperazine (MeOPP), 1-(3,4-methylenedioxybenzyl)piperazine (MDBP), y-butyrolactone (GBL), and 1,4-butanediol (1,4-BD). Of these, tapentadol, BZP, GBL and 1,4-BD were recommended for critical review. Issues identified for consideration at future Expert Committee meetings are also listed. Furthermore, the report discusses the use of terms, the use of pharmacovigilance data for the assessment of abuse and dependence potential, balancing medical availability and prevention of abuse of medicines manufactured from controlled substances, and improving the process for substance evaluation. |
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1,4-butanediol 1971 Convention abuse and dependence abuse potential accessed 15 July accessibility of controlled addiction assessment Commission on Narcotic Committee on Drug controlled medicines controlled substances Convention on Narcotic Convention on Psychotropic countries dependence potential Dextromethorphan dronabinol drug control conventions Drug Dependence ECDD meeting Economic and Social Essential Medicines Expert Committee concluded Expert Committee noted Expert Committee recommended Geneva guidelines http://whqlibdoc INCB international control international drug control International Narcotics Control International Nonproprietary Name ISBN ketamine List of Essential mCPP MDBP MDBZP MDMA MeOPP Model List Narcotic Drugs Report Narcotics Control Board never been licensed opioid dependence oripavine pharmacovigilance piperazine derivative pre-review Professor psychoactive substances Psychotropic Substances public health receptor review of psychoactive Schedule IV Secretariat Single Convention Social Council substance evaluation substances for international Tapentadol Technical Report Series Temporary Adviser terminology TFMPP thirty-fifth meeting thirty-fourth meeting United Nations Uppsala Monitoring Centre World Health Organization