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activity analysis APOBEC3G applications associated autophagy behaviour Biol biology brain calpain cancer candidates cell biology Center changes channel chromatin chromosome climate complex corneal CRTC2 dark matter detected diatoms disease DNA methylation domain dynamics e-mail effect electron emission energy experience expression function genes genetic genome sequence genotype Holliday junction human adult GSCs human genome imaging Institute interactions melanotrope Methods methylation mice molecular molecules mutations nanowires Nature nature publishing group NATUREJOBS neurons Neurosci nuclear observed optical paddle motifs Paneth cells paper at www.nature.com/nature Phys position PPAR-y predation predicted protein quantum quantum dot receptor region response Rhcg role sample says Science scientific scientists signal simulations SNPs specific stem cells structure Supplementary Fig Supplementary Information Supplementary Table target temperature tion toxin transcription tumour University variants wild-type yeast