NatureSir Norman Lockyer Macmillan Journals Limited, 2007 |
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Stran 198
... TRPM8 Positive. LETTERS Sensory nerve fibres can detect changes in temperature over a remarkably wide range , a process that has been proposed to involve direct activation of thermosensitive excitatory transient receptor potential ( TRP ) ...
... TRPM8 Positive. LETTERS Sensory nerve fibres can detect changes in temperature over a remarkably wide range , a process that has been proposed to involve direct activation of thermosensitive excitatory transient receptor potential ( TRP ) ...
Stran 199
... TRPM8 - deficient neurons showed normal responses to heat . When exposed to a heat ramp ( 30 to 45 ° C in 45 s ) , 44 % of trigeminal neurons from TRPM8 mice were heat - sensitive , compared with 41 % from wild - type littermates ...
... TRPM8 - deficient neurons showed normal responses to heat . When exposed to a heat ramp ( 30 to 45 ° C in 45 s ) , 44 % of trigeminal neurons from TRPM8 mice were heat - sensitive , compared with 41 % from wild - type littermates ...
Stran 200
... TRPM8 + / + TRPM8 - / - C 10 0 TRPM8 + / + TRPM8 - / - 4 4 3 2- 1 0 20 0 0 50 Menthol 100 150 200 Time ( s ) 60 Wild type TRPM8-- TRPV1-- 40 20- *** 3- 2- 1- 0 20- Menthol 0 0 50 100 150 200 Time ( s ) ** 0 12 ° C 22 ° C 45 ° C Thermal ...
... TRPM8 + / + TRPM8 - / - C 10 0 TRPM8 + / + TRPM8 - / - 4 4 3 2- 1 0 20 0 0 50 Menthol 100 150 200 Time ( s ) 60 Wild type TRPM8-- TRPV1-- 40 20- *** 3- 2- 1- 0 20- Menthol 0 0 50 100 150 200 Time ( s ) ** 0 12 ° C 22 ° C 45 ° C Thermal ...
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