NatureSir Norman Lockyer Macmillan Journals Limited, 2007 |
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Stran 207
... topotecan , induce cell death by poisoning DNA topoisomerase I , an enzyme capable of removing DNA supercoils11 . Topotecan is thought to stabilize a covalent topoisomerase - DNA complex , rendering it an obstacle to DNA replication ...
... topotecan , induce cell death by poisoning DNA topoisomerase I , an enzyme capable of removing DNA supercoils11 . Topotecan is thought to stabilize a covalent topoisomerase - DNA complex , rendering it an obstacle to DNA replication ...
Stran 208
... topotecan and TopIB . The consequences of these interactions are also observed in living cells , suggesting an alternative mechanism for cell death . To examine the consequences of camptothecin binding on TopІВ swivel function , we ...
... topotecan and TopIB . The consequences of these interactions are also observed in living cells , suggesting an alternative mechanism for cell death . To examine the consequences of camptothecin binding on TopІВ swivel function , we ...
Stran 209
... topotecan molecule bound to the TopIB - DNA complex . Highly relevant for any consideration of the ' collision ' model is the lifetime of the covalent complex . Consequently , we asked over what timescale topotecan remains bound , and ...
... topotecan molecule bound to the TopIB - DNA complex . Highly relevant for any consideration of the ' collision ' model is the lifetime of the covalent complex . Consequently , we asked over what timescale topotecan remains bound , and ...
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activity adhesive analysis applications beam binding Biol biology boson brain calmodulin carbon CD1d CDNF CERN channel clones collisions complex density detected detector ecosystem electron energy epiblast EpiSCs experiments expression factors function gene genetic genome Hadron Higgs Higgs boson human imaging Institute interactions iPS cells Laboratory Large Hadron Collider levels magnetic measurements mechanism methylation mice mimics molecular mouse ES cells mutant Nanog Nanog iPS Nature nature publishing group naturejobs neurons observed Oct4 paper at www.nature.com/nature particles peptide photon Phys physics plants pluripotent position potential production protein quantum quark-gluon plasma quarks receptor RNAi RNAP scientific scientists sequence signalling silicon siRNA Sox2 species standard model stem cells structure substrate supercoils Supplementary Fig Supplementary Information Supplementary Table surface target temperature theory tion topotecan transcription transform fault transgenic TRPM8 University wild-type