Nature, Količina 428Sir Norman Lockyer Macmillan Journals Limited, 2004 |
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Stran 78
... hCDC4 is genetically altered , its coding exons were amplified by polymerase chain reaction ( PCR ) from 190 colorectal tumours and sequenced . Somatic mutations in the hCDC4 gene were found in 22 of the 190 samples . Nonsense mutations ...
... hCDC4 is genetically altered , its coding exons were amplified by polymerase chain reaction ( PCR ) from 190 colorectal tumours and sequenced . Somatic mutations in the hCDC4 gene were found in 22 of the 190 samples . Nonsense mutations ...
Stran 79
... hCDC4 gene in DLD - 1 , another karyotypically stable colorectal cancer cell line . We obtained a clone in which both alleles were disrupted ( Fig . 2b , c ) , and the phenotype of this clone hCDC4 HE Z 3 ' NeopA -4.2 kb P 5 ' Neo -2.0 ...
... hCDC4 gene in DLD - 1 , another karyotypically stable colorectal cancer cell line . We obtained a clone in which both alleles were disrupted ( Fig . 2b , c ) , and the phenotype of this clone hCDC4 HE Z 3 ' NeopA -4.2 kb P 5 ' Neo -2.0 ...
Stran 80
... hCDC4 . To determine whether the increased abundance of cyclin E was sufficient to reproduce the phenotype observed on inactivation of hCDC4 , we overexpressed cyclin E in DLD - 1 and HSG cells through transient transfection . An ...
... hCDC4 . To determine whether the increased abundance of cyclin E was sufficient to reproduce the phenotype observed on inactivation of hCDC4 , we overexpressed cyclin E in DLD - 1 and HSG cells through transient transfection . An ...
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of genetically modified grain | 8 |
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