Nature, Količina 452Sir Norman Lockyer Macmillan Journals Limited, 2008 |
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Stran 183
... PKM2 did not ffect phosphotyrosine peptide binding ( data not shown ) , mutation of lysine 433 - located within the unique region of PKM2 , which lies at the lip of the pocket - to glutamate abolished phosphotyrosine peptide binding ...
... PKM2 did not ffect phosphotyrosine peptide binding ( data not shown ) , mutation of lysine 433 - located within the unique region of PKM2 , which lies at the lip of the pocket - to glutamate abolished phosphotyrosine peptide binding ...
Stran 184
... PKM2 consistently result in greater decreases in PKM2 activity ( data not shown ) . In addition , as little as 1 μM phos- photyrosine peptide can inhibit PKM2 activity , suggesting that a meaningful interaction between PKM2 and tyrosine ...
... PKM2 consistently result in greater decreases in PKM2 activity ( data not shown ) . In addition , as little as 1 μM phos- photyrosine peptide can inhibit PKM2 activity , suggesting that a meaningful interaction between PKM2 and tyrosine ...
Stran 185
... PKM2 in glycolysis under cell culture conditions , is important for its role in cell proliferation . Similar results ... PKM2 is important for cell proliferation . cl pLHCX , cells with empty rescue vector and control shRNA ; kd pLHCX ...
... PKM2 in glycolysis under cell culture conditions , is important for its role in cell proliferation . Similar results ... PKM2 is important for cell proliferation . cl pLHCX , cells with empty rescue vector and control shRNA ; kd pLHCX ...
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activity adenovirus analysis antibody applications assay atoms binding Biol Biology cancer candidate carbon CD8 T cells Center complex correlation CP violation crystals cytosine desalination detected differentiation DNA methylation drug effect electron energy environment enzyme experiments function gene expression genetic genome human images increase infection Institute interactions isotopic ketyl Lett levels magnetic mantle measured mechanism MEFs membrane methylation mGluR2 mice microRNA midge molecular molecules mouse mRNA mutant Nature Nature Publishing Group Naturejobs neuronal observed online version paper at www.nature.com/nature pars tuberalis peptide peridotites phosphotyrosine photon Phys PKM2 plant plasmasphere population position predicted production protein pS2 promoter pyruvate kinase quantum receptor region regulation response ribosome role samples SATB1 says Science scientists sequence shown shRNA signal specific structure studies Supplementary Fig Supplementary Table target tion transcription tumour University vivo wild-type